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Journal of clinical and translational hepatology 6(2): 127-134
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The level of IGF-1 was higher in the serum during daytime and in the liver during night-time, but lower in the serum during night-time and in the liver during daytime ( BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels ( CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research
Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, et al
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